Physiological parameters governing the action of pancreatic lipase
نویسندگان
چکیده
منابع مشابه
Physiological parameters governing the action of pancreatic lipase.
The most widely used pharmacological therapies for obesity and weight management are based on inhibition of gastrointestinal lipases, resulting in a reduced energy yield of ingested foods by reducing dietary lipid absorption. Colipase-dependent pancreatic lipase is believed to be the major gastrointestinal enzyme involved in catalysis of lipid ester bonds. There is scant literature on the actio...
متن کاملInfluence of Bile Salt, Ph, and Time on the Action of Pancreatic Lipase; Physiological Implications.
The difference in relative rates of hydrolysis of the 1,3and the 2-ester bonds of triglycerides (50-100: 1) catalyzed by pancreatic lipase results in a rapid net hydrolysis of the 1,3-ester bonds at an enzyme level that effects only limited hydrolysis of the 2-ester bond. The net hydrolysis of the 1,3or primary ester bonds proceeds until a steady state has been established between rate of hydro...
متن کاملInfluence of bile salt, pH, and time on the action of pancreatic lipase; physiological implications
The difference in relative rates of hydrolysis of the 1,3and the 2-ester bonds of triglycerides (50-100: 1) catalyzed by pancreatic lipase results in a rapid net hydrolysis of the 1,3-ester bonds at an enzyme level that effects only limited hydrolysis of the 2-ester bond. The net hydrolysis of the 1,3or primary ester bonds proceeds until a steady state has been established between rate of hydro...
متن کاملMode of Action of Pancreatic Lipase*
In the past the specificity of lipase action for fats has been to some extent taken for granted. Pancreas extracts were known to hydrolyze all the ordinary glycerides (except possibly the stearins) and this behavior defined the enzyme lipase. There have been good reasons for supposing that stearins constituted no exception in principle, but were merely attacked very slowly. Actually, tristearin...
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ژورنال
عنوان ژورنال: Nutrition Research Reviews
سال: 2010
ISSN: 0954-4224,1475-2700
DOI: 10.1017/s0954422410000028